Predicting brain age with global-local attention network from multimodal neuroimaging data: Accuracy, generalizability, and behavioral associations.

Abstract

Brain age, an emerging biomarker for brain diseases and aging, is typically predicted using single-modality T1-weighted structural MRI data. This study investigates the benefits of integrating structural MRI with diffusion MRI to enhance brain age prediction. We propose an attention-based deep learning model that fuses global-context information from structural MRI with local details from diffusion metrics. The model was evaluated using two large datasets: the Human Connectome Project (HCP, n = 1064, age 22-37) and the Cambridge Center for Aging and Neuroscience (Cam-CAN, n = 639, age 18-88). It was tested for generalizability and robustness on three independent datasets (n = 546, age 20-86), reproducibility on a test-retest dataset (n = 44, age 22-35), and longitudinal consistency (n = 129, age 46-92). We also examined the relationship between predicted brain age and behavioral measures. Results showed that the multimodal model improved prediction accuracy, achieving mean absolute errors (MAEs) of 2.44 years in the HCP dataset (sagittal plane) and 4.36 years in the Cam-CAN dataset (axial plane). The corresponding R