Improving understanding of ferroptosis: Molecular mechanisms, connection with cellular senescence and implications for aging.

Diego De Leon-Oliva, Diego Liviu Boaru, Ana M Minaya-Bravo, Patricia De Castro-Martinez, Oscar Fraile-Martinez, Cielo Garcia-Montero, David Cobo-Prieto, Silvestra Barrena-Blázquez, Laura Lopez-Gonzalez, Agustín Albillos, Melchor Alvarez-Mon, Miguel A Saez, Raul Diaz-Pedrero, Miguel A Ortega

Department of Medicine and Medical Specialities, (CIBERehd), Faculty of Medicine and Health Sciences, University of Alcalá, 28801, Alcala de Henares, Spain.Department of Medicine and Medical Specialities, (CIBERehd), Faculty of Medicine and Health Sciences, University of Alcalá, 28801, Alcala de Henares, Spain. · pubmed

Paper

Abstract

In the face of cell damage, cells can initiate a response ranging from survival to death, the balance being crucial for tissue homeostasis and overall health. Cell death, in both accidental and regulated forms, plays a fundamental role in maintaining tissue homeostasis. Among the regulated mechanisms of cell death, ferroptosis has garnered attention for its iron-dependent phospholipid (PL) peroxidation and its implications in aging and age-related disorders, as well as for its therapeutic relevance. In this review, we provide an overview of the mechanisms, regulation, and physiological and pathological roles of ferroptosis. We present new insights into the relationship between ferroptosis, cellular senescence and aging, emphasizing how alterations in ferroptosis pathways contribute to aging-related tissue dysfunction. In addition, we examine the therapeutic potential of ferroptosis in aging-related diseases, offering innovative insights into future interventions aimed at mitigating the effects of aging and promoting longevity.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses ferroptosis and its connection to cellular senescence and aging, which are relevant topics in longevity research. It explores the mechanisms and implications of ferroptosis in the context of aging-related tissue dysfunction and potential therapeutic interventions, indicating a focus on root causes of aging rather than merely treating symptoms. However, while the insights presented are valuable, they appear to be more of a solid review of existing knowledge rather than groundbreaking findings, hence the moderate impact score.

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