Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the US POINTER Trial.

Mark A Espeland, Yitbarek N Demesie, Kay Loni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan

Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. · pubmed

Paper

Abstract

Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index (FI) developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions.

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Research summary

The paper investigates the associations between frailty indices and lifestyle factors within the context of a multidomain intervention trial aimed at addressing biological aging. While it contributes to understanding how lifestyle factors may influence frailty, which is related to aging, the findings appear to be more descriptive and correlational rather than providing novel insights or interventions that directly target the root causes of aging. Thus, it represents solid research but with limited impact on the field of longevity.

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