Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort.

Marianna Piras, Jue Lin, Marie Catherine Sadler, Setareh Ranjbar, Claire Grosu, Nermine Laaboub, Martin Preisig, Franziska Gamma, Kerstin Jessica Plessen, Armin von Gunten, Philippe Conus, Zoltan Kutalik, Chin B Eap

Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Lausanne, Prilly, Switzerland. [email protected] of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Lausanne, Prilly, Switzerland. [email protected]. · pubmed

Paper

Abstract

Weight-inducing psychotropic treatments are risk factors for age-related diseases such as cardiovascular disorders, which are associated with both inflammation and telomere length shortening. With a longitudinal design, the present study evaluates telomere length trajectories after 1 year of weight-inducing psychotropic medication, accounting for weight changes and the inflammatory biomarker high-sensitivity C-Reactive Protein (CRP). Among 200 patients, an overall median telomere shortening of -41.2 bp was observed (p = 0.014), which is comparable with the general population's yearly telomere attrition. Linear regression showed on average -93.1 and -58.9 bp of further telomere shortening per five units of BMI for BMI values < or ≥30 kg/m

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between psychotropic-induced weight gain and telomere length, which is relevant to aging and age-related diseases. However, it primarily focuses on the effects of medication and weight changes rather than addressing the root causes of aging or providing insights into lifespan extension. The findings contribute to understanding telomere dynamics in a specific context but do not present groundbreaking advancements in the field of longevity research.

Author of this paper? Send a correction.