Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics.

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu, Rui Zhou, Chenchen Yuan, Yanbing Ding, Weiming Xiao, Weijuan Gong, Qing Shan, Guotao Lu, Hongwei Xu

Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China; Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China. · pubmed

Paper

Abstract

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cells' high-throughput sequencing data from the GEO public database. Utilizing bioinformatics techniques, we identified the key regulatory factor YY1 in the aging process of pancreatic islets. We observed a significant decrease in the expression of YY1 in a D-gal-induced mouse model of pancreatic aging and an H

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Research summary

The paper investigates the role of the transcription factor YY1 in the aging process of pancreatic beta cells, which is directly related to the mechanisms of aging and age-related diseases such as impaired glucose tolerance. While the study employs bioinformatics to identify a regulatory factor, the findings appear to be a solid contribution to understanding the aging process in a specific cell type, but they do not present groundbreaking insights that would significantly advance the field of longevity research.

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