Dawn-to-dusk intermittent fasting is associated with overexpression of autophagy genes: A prospective study on overweight and obese cohort.

Lara J Bou Malhab, Mohamed I Madkour, Dana N Abdelrahim, Leen Eldohaji, Maha Saber-Ayad, Nabil Eid, Wael M Abdel-Rahman, MoezAlIslam E Faris

Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates. · pubmed

Paper

Abstract

A growing body of evidence supports the impact of intermittent fasting (IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of the catabolic autophagic machinery (LAMP2, LC3B, ATG5, and ATG4D) has protective effects against degenerative aging and chronic diseases. This research examined the changes in the expression of the aforementioned genes upon the observance of dawn-to-dusk IF among metabolically healthy participants with overweight and obesity.

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Research summary

The paper investigates the effects of dawn-to-dusk intermittent fasting on the expression of autophagy genes, which are linked to longevity and healthy aging. While it contributes to the understanding of dietary interventions and their potential role in modulating biological processes associated with aging, the findings appear to be incremental rather than groundbreaking. The study's focus on a specific fasting regimen in a limited cohort suggests solid research, but its overall impact on the broader field of longevity research is limited.

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