Clerodendrum trichotomum Extract Attenuates UV-B-Induced Skin Impairment in Hairless Mice by Inhibiting MAPK Signaling.

Ki Mo Kim, A-Rang Im, Ki-Shuk Shim, A Yeong Lee, Taesoo Kim, Sung-A Choi, Kung-Woo Nam, Sanghyun Lee, Jin Won Hyun, Sungwook Chae

KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. · pubmed

Paper

Abstract

Exposure to solar ultraviolet-B (UV-B) radiation significantly accelerates skin aging by inducing the expression of matrix metalloproteinases (MMPs) such as MMP-1, leading to alterations in the extracellular matrix and consequent photoaging. Some plant components, renowned for their UV-absorbing and antioxidative properties, show potential for mitigating photoaging by reducing UV-B-induced MMP levels. In this context, we explored the inhibitory effects of Clerodendrum trichotomum extract (CTE) on UV-B-induced skin damage.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of Clerodendrum trichotomum extract on UV-B-induced skin damage, which is related to photoaging—a process associated with the aging of skin. While it addresses a factor contributing to skin aging, the focus is primarily on mitigating symptoms rather than addressing the root causes of aging or lifespan extension. Therefore, while it contributes to the understanding of skin aging mechanisms, its overall impact on the broader field of longevity research is limited.

Author of this paper? Send a correction.