Healthy and Unhealthy Aging and the Human Microbiome.
Abstract
An altered gut microbiome is a feature of many multifactorial diseases, and microbiome effects on host metabolism, immune function, and possibly neurological function are implicated. Increased biological age is accompanied by a change in the gut microbiome. However, age-related health loss does not occur uniformly across all subjects but rather depends on differential loss of gut commensals and gain of pathobionts. In this article, we summarize the known and possible effects of the gut microbiome on the hallmarks of aging and describe the most plausible mechanisms. Understanding and targeting these factors could lead to prolonging health span by rationally maintaining the gut microbiome.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses the relationship between the gut microbiome and aging, focusing on how alterations in the microbiome can influence health span and the aging process. This aligns with longevity research as it addresses potential mechanisms that could be targeted to improve health outcomes in aging individuals. However, while the findings are solid, they do not present groundbreaking insights or transformative approaches that would significantly advance the field, hence the moderate impact score.
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