Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model.

Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li

College of Food Science and Technology, Key Laboratory of Environment Correlative Food Science, Huazhong Agricultural University, Wuhan 430070, China. [email protected] of Food Science and Technology, Key Laboratory of Environment Correlative Food Science, Huazhong Agricultural University, Wuhan 430070, China. [email protected]. · pubmed

Paper

Abstract

Ergothioneine (EGT) is a sulfur-containing amino acid with strong antioxidant activity. In this study, a D-galactose induced mouse aging model was used to investigate the anti-aging effects of EGT. EGT intervention could significantly improve the recognition memory of aging mice. Additionally, it improved the D-galactose induced decrease in the number of neurones, enhanced the levels of cAMP and BDNF in the brain, and increased the density and expression of PSD95 in aging mice. Meanwhile, EGT could attenuate oxidative stress by reducing the content of MDA and enhancing T-SOD activity

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of ergothioneine on cognitive function and neuroinflammation in an aging model, addressing mechanisms that could be linked to aging processes. However, while it presents solid research, the findings appear to be incremental rather than groundbreaking, focusing on a specific compound's effects rather than broader implications for longevity or aging interventions.

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