Chronic social stress induces p16-mediated senescent cell accumulation in mice.

Carey E Lyons, Jean Pierre Pallais, Seth McGonigle, Rachel P Mansk, Charles W Collinge, Matthew J Yousefzadeh, Darren J Baker, Patricia R Schrank, Jesse W Williams, Laura J Niedernhofer, Jan M van Deursen, Maria Razzoli, Alessandro Bartolomucci

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA. · pubmed

Paper

Abstract

Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology underlying this phenomenon remains unclear. Here we assessed the effect of chronic stress on cellular senescence-a hallmark of aging. Exposure to restraint stress, a psychological non-social stress model, increased p21

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Research summary

The paper investigates the relationship between chronic social stress and cellular senescence, which is a key aspect of aging biology. By focusing on the accumulation of senescent cells as a potential mechanism linking stress to aging-related diseases, it addresses a fundamental aspect of aging. However, while the findings contribute to our understanding of the effects of stress on cellular aging, they do not present a significant breakthrough or novel therapeutic approach, limiting their overall impact.

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