Deciphering influence of donor age on adipose-derived stem cells: in vitro paracrine function and angiogenic potential.

Chloe Trotzier, Clement Bellanger, Hakima Abdessadeq, Philippe Delannoy, Ali Mojallal, Celine Auxenfans

Advanced Research, L'Oréal Research and Innovation, 1, Av. Eugene Schueller, 93600, Aulnay sous Bois, France. [email protected] Research, L'Oréal Research and Innovation, 1, Av. Eugene Schueller, 93600, Aulnay sous Bois, France. [email protected]. · pubmed

Paper

Abstract

As fat grafting is commonly used as a filler, Adipose-derived stem/stromal cells (ASC) have been reported to be key player in retention rate. Paracrine and differentiation potential of those cells confer them strong pro-angiogenic capacities. However, a full characterization of the influence of aging on ASC has not been reported yet. Here we've investigated the effect of age on paracrine function, stemness and angiogenic potential of ASC.

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Research summary

The paper investigates the influence of donor age on adipose-derived stem cells (ASC) and their paracrine function and angiogenic potential, which is relevant to understanding how aging affects stem cell functionality. However, while it contributes to the knowledge of ASC in the context of aging, it does not directly address root causes of aging or lifespan extension. The findings may have implications for regenerative medicine but are more incremental than groundbreaking in the broader context of longevity research.

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