De novo biosynthesis and nicotinamide biotransformation of nicotinamide mononucleotide by engineered yeast cells.

Yanna Ren, Bei Han, Shijie Wang, Xingbin Wang, Qi Liu, Menghao Cai

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. · pubmed

Paper

Abstract

β-Nicotinamide mononucleotide (NMN) is a precursor of NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the biosynthesis and biotransformation of nicotinamide mononucleotide (NMN), which is directly related to NAD+ metabolism, a critical factor in cellular energy metabolism and aging. By engineering yeast cells to produce NMN, the research could contribute to understanding and potentially addressing aspects of aging at a biochemical level. However, while the findings are solid, they appear to be an incremental advance rather than a groundbreaking discovery, limiting their overall impact on the field of longevity research.

Author of this paper? Send a correction.