Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.

Li Chen, Karen Mei-Ling Tan, Jia Xu, Priti Mishra, Sartaj Ahmad Mir, Min Gong, Kothandaraman Narasimhan, Bryan Ng, Jun Shi Lai, Mya Thway Tint, Shirong Cai, Suresh Anand Sadananthan, Navin Michael, Jadegoud Yaligar, Sambasivam Sendhil Velan, Melvin Khee Shing Leow, Kok Hian Tan, Jerry Chan, Michael J Meaney, Shiao-Yng Chan, Yap Seng Chong, Johan G Eriksson

Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [email protected] for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. [email protected]. · pubmed

Paper

Abstract

Phenotypic age (PhenoAge), a widely used marker of biological aging, has been shown to be a robust predictor of all-cause mortality and morbidity in different populations. Existing studies on biological aging have primarily focused on individual domains, resulting in a lack of a comprehensive understanding of the multi-systemic dysregulation that occurs in aging.

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Research summary

The paper investigates biological aging through multi-omics approaches in a specific demographic, which contributes to understanding the mechanisms of aging. However, it primarily focuses on phenotypic age as a marker rather than addressing the root causes of aging or proposing interventions for lifespan extension. Thus, while it adds to the body of knowledge, its impact is limited and more incremental than transformative.

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