Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways.

Mohammed Alrouji, Saleha Anwar, Kumar Venkatesan, Moyad Shahwan, Md Imtaiyaz Hassan, Asimul Islam, Anas Shamsi

Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi Arabia. Electronic address: [email protected]. · pubmed

Paper

Abstract

Ageing is a major risk factor for various chronic diseases and offers a potential target for developing novel and broadly effective preventatives or therapeutics for age-related conditions, including those affecting the brain. Mechanisms contributing to ageing have been summarized as the hallmarks of ageing, with iron imbalance being one of the major factors. Ferroptosis, an iron-mediated lipid peroxidation-induced programmed cell death, has recently been implicated in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Addressing ferroptosis offers both opportunities and challenges for treating neurodegenerative diseases, though the specific mechanisms remain unclear. This research explores the key processes behind how ferroptosis contributes to brain ageing, with a focus on the complex signaling networks that are involved. The current article aims to uncover that how ferroptosis, a specific type of cell death, may drive age-related changes in the brain. Additionally, the article also unveils its role in neurodegenerative diseases, discussing how understanding these mechanisms could open up new therapeutic avenues.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the role of ferroptosis in neurodegeneration and its implications for brain ageing, which aligns with the exploration of mechanisms contributing to ageing and potential therapeutic targets. However, while it presents solid research, the findings appear to be incremental rather than groundbreaking, limiting its overall impact on the field of longevity research.

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