Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging.

Khalid Al-Regaiey

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. [email protected] of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. [email protected]. · pubmed

Paper

Abstract

In the last forty years, the number of people over 60 years of age has increased significantly owing to better nutrition and lower rates of infectious diseases in developing countries. Aging significantly impacts adipose tissue, which plays crucial role in hormone regulation and energy storage. This can lead to imbalances in glucose, and overall energy homeostasis within the body. Aging is irreversible phenomena and potentially causing lipid infiltration in other organs, leading to systemic inflammation, metabolic disorders. This review investigates various pathways contributing to aging-related defects in adipogenesis, such as changes in adipose tissue function and distribution. Polyphenols, a diverse group of natural compounds, can mitigate aging effects via free radicals, oxidative stress, inflammation, senescence, and age-related diseases. Polyphenols like resveratrol, quercetin and EGCG exhibit distinct mechanisms and regulate crucial pathways, such as the TGF-β, AMPK, Wnt, PPAR-γ, and C/EBP transcription factors, and influence epigenetic modifications, such as DNA methylation and histone modification. This review highlights the critical importance of understanding the intricate relationship between aging and adipogenesis for optimizing well-being with increasing age. These findings highlight the therapeutic potential of polyphenols like quercetin and resveratrol in enhancing adipose tissue function and promoting healthy aging.

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Research summary

The paper addresses the relationship between adipogenesis and aging, focusing on the role of polyphenols in potentially mitigating age-related defects in adipose tissue function. This aligns with longevity research as it explores mechanisms that could influence aging processes. However, the findings are primarily a review of existing literature rather than presenting new experimental data or significant breakthroughs, which limits its overall impact on the field.

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