Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice.

Patricia Baumgarten, Tobias Jung, Christiane Ott, Tilman Grune

Department of Molecular Toxicology, German Institut of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14585, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Potsdamer Straße 58, Berlin, Germany.Department of Molecular Toxicology, German Institut of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14585, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Potsdamer Straße 58, Berlin, Germany. · pubmed

Paper

Abstract

This study investigates the differences in the heart response to an 8-week high-fat diet between young and aged mice. Isolated cardiomyocytes reveal a significant lower level in the lipid droplet-associated protein Plin5 in aged mice. High-fat diet, however, leads to an induction of Plin5 in aged mice and a low-response of lipid metabolism, whereas in cardiomyocytes from young animals the Plin5 level was largely unaffected by high-fat diet whereas several lipid metabolizing enzymes were induced. Therefore, the high-fat diet induced lipid droplet accumulation is more pronounced in cardiomyocytes isolated from aged animals.

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Research summary

The study examines the differential response of cardiomyocytes to a high-fat diet in young versus aged mice, which is relevant to understanding age-related metabolic changes and their implications for heart health in the context of aging. However, while it provides insights into lipid metabolism and the role of Plin5, the findings are incremental and do not address root causes of aging or lifespan extension directly. Thus, the impact is limited.

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