Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk.

Sandro Marini, Tamara N Kimball, Ernst Mayerhofer, Reinier W P Tack, Jasper R Senff, Savvina Prapiadou, Cyprien A Rivier, Jonathan Duskin, Christina Kourkoulis, Guido J Falcone, Nirupama Yechoor, Rudolph E Tanzi, Jonathan Rosand, Sanjula Singh, Livia Parodi, Christopher D Anderson

From the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.From the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT. · pubmed

Paper

Abstract

The 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, including stroke, late-life depression (LLD), and dementia. A higher BCS at baseline is associated with a lower risk of these outcomes. We aimed to investigate whether the associations between BCS and stroke, LLD, and dementia risks are independent of genetic predisposition for these conditions and quantify the effect of healthy lifestyle across genetic risk distributions for these outcomes.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between health-related behaviors and the risk of common age-related brain diseases, which is pertinent to longevity research. However, it primarily focuses on lifestyle adjustments rather than addressing the root causes of aging or mechanisms for lifespan extension. The findings contribute to the understanding of how lifestyle factors can mitigate risks associated with genetic predispositions, but the impact is limited as it does not propose novel interventions or insights that significantly advance the field.

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