Cytosolic

Mads M Foged, Emeline Recazens, Sylvain Chollet, Miriam Lisci, George E Allen, Boris Zinshteyn, Doha Boutguetait, Christian Münch, Vamsi K Mootha, Alexis A Jourdain

Department of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.Department of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland. · pubmed

Paper

Abstract

Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a nucleo-cytosolic methyltransferase that exhibits genetic codependency with mitochondria. We determine transcriptional and translational profiles of

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Research summary

The paper investigates the role of N6AMT1 in mitochondrial biogenesis and its genetic codependency with mitochondria, which is relevant to the mechanisms of aging and metabolic processes. However, while it addresses important biological pathways, the findings appear to be more of a solid research contribution rather than a groundbreaking advance in understanding the root causes of aging or lifespan extension.

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