FOXO3 Longevity Genotype Mitigates Risk Posed by Hypertension on Incident Coronary Artery Disease in Middle-Aged Men: Kuakini Honolulu Heart Program.

Randi Chen, Brian J Morris, Timothy A Donlon, Kazuma Nakagawa, Richard C Allsopp, Bradley J Willcox, Kamal H Masaki

Department of Research, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii.Department of Research, Kuakini Honolulu Heart Program, Center of Biomedical Research Excellence (COBRE) for Clinical and Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii. · pubmed

Paper

Abstract

This study tested whether the carriage of the longevity-associated G-allele of FOXO3 SNP rs2802292 (TG/GG) protects against incident coronary artery disease (CAD) in men with hypertension.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study investigates the association between a specific genetic variant (FOXO3 SNP rs2802292) and its potential protective effects against coronary artery disease in the context of hypertension, which is relevant to understanding longevity and age-related health outcomes. However, while it contributes to the understanding of genetic factors in longevity, the findings are somewhat incremental and do not fundamentally alter the current understanding of aging mechanisms or provide a novel approach to lifespan extension.

Author of this paper? Send a correction.