Opportunities and challenges of foodborne polyphenols applied to anti-aging health foods.

Hong Zhuang, Xiaoliang Zhang, Sijia Wu, Pang Yong, Haiyang Yan

College of Food Science and Engineering, Jilin University, Changchun, 130062 Jilin China.College of Food Science and Engineering, Jilin University, Changchun, 130062 Jilin China. · pubmed

Paper

Abstract

With the increasing proportion of the global aging population, aging mechanisms and anti-aging strategies become hot topics. Nonetheless, the safety of non-natural anti-aging active molecule and the changes in physiological function that occur during aging have not been clarified. There is therefore a need to develop safer pharmaceutical interventions for anti-aging. Numerous types of research have shown that food-derived biomolecules are of great interest due to their unique contribution to anti-aging safety issues and the prevention of degenerative diseases. Among these, polyphenolic organic compounds are widely used in anti-aging research for their ability to mitigate the physiological functional changes that occur during aging. The mechanisms include the free radical theory, immune aging theory, cellular autophagy theory, epigenetic modification theory, gut microbial effects on aging theory, telomere shortening theory, etc. This review elucidates the mechanisms underlying the anti-aging effects of polyphenols found in food-derived bioactive molecules, while also addressing the challenges associated with anti-aging pharmaceuticals. The review concludes by offering insights into the current landscape of anti-aging active molecule research, aiming to serve as a valuable resource for further scholarly inquiry.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the role of foodborne polyphenols in anti-aging, focusing on their mechanisms and potential as safer alternatives to pharmaceutical interventions. While it addresses important aspects of aging and offers insights into the anti-aging effects of natural compounds, the review primarily synthesizes existing knowledge rather than presenting novel findings or significant advancements in the field. Thus, it contributes to the understanding of anti-aging strategies but does so in a limited manner.

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