BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer.

Renju Pun, Niti Kumari, Rodaina Hazem Monieb, Sachin Wagh, Brian J North

Biomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA.Biomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, USA. · pubmed

Paper

Abstract

Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate chromosomal segregation and preventing aneuploidy. BubR1 levels have been shown to naturally decline with age and its loss is associated with various age-related pathologies. Sirtuins, a class of NAD

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Research summary

The paper discusses the role of BubR1 in chromosomal segregation and its decline with age, linking it to genomic instability and age-related pathologies, which are relevant to the underlying mechanisms of aging. However, while it presents solid research, it does not propose direct interventions or solutions to aging itself, limiting its overall impact on the field of longevity research.

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