ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans.
Abstract
Variations of individual lifespans within genetically identical populations in homogenous environments are remarkable, with the cause largely unknown. Here, we show the expression dynamic of the Caenorhabditis elegans fatty acid elongase ELO-6 during aging predicts individual longevity in isogenic populations. elo-6 expression is reduced with age. ELO-6 expression level exhibits obvious variation between individuals in mid-aged worms and is positively correlated with lifespan and health span. Interventions that prolong longevity enhance ELO-6 expression stability during aging, indicating ELO-6 is also a populational lifespan predictor. Differentially expressed genes between short-lived and long-lived isogenic worms regulate lifespan and are enriched for PQM-1 binding sites. pqm-1 in young to mid-aged adults causes individual ELO-6 expression heterogeneity and restricts health span and life span. Thus, our study identifies ELO-6 as a predictor of individual and populational lifespan and reveals the role of pqm-1 in causing individual health span variation in the mid-aged C. elegans.
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Research summary
The paper investigates the expression of ELO-6 in relation to individual longevity in isogenic populations of C. elegans, which is directly relevant to understanding the biological mechanisms of aging and lifespan variation. While the findings contribute to the field by identifying a potential predictor of longevity and exploring the role of pqm-1, the overall impact appears to be solid but limited, as it primarily adds to existing knowledge without presenting groundbreaking insights or novel interventions for lifespan extension.
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