Activation of the apelin/APJ system by vitamin D attenuates age-related muscle atrophy.

Yoo Jeong Lee, Gyu Hee Kim, Da Som Lee, Hyeon-Ju Jeong, Joo Hyun Lim

Division of Endocrine and Kidney Disease Research, Department of Chronic Disease Convergence Research, National Institute of Health, Cheongju 28159, Republic of Korea. Electronic address: [email protected]. · pubmed

Paper

Abstract

Age-related frailty and reduced physical activity contribute to a degenerative loss of muscle mass, function, and strength, which is known as sarcopenia. Increasing evidence has shown that vitamin D has beneficial effects on the muscle health. However, the molecular mechanisms of vitamin D have not been fully elucidated. In this study, we aimed to demonstrate whether vitamin D can overcome muscle atrophy due to aging, especially with respect to the regulation of myokines.

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Research summary

The paper addresses the activation of the apelin/APJ system by vitamin D in the context of age-related muscle atrophy, which is a significant aspect of sarcopenia and aging. While it contributes to understanding the molecular mechanisms behind muscle health in aging, it primarily focuses on a specific intervention rather than addressing the root causes of aging itself. Therefore, while it is relevant to longevity research, its impact is limited as it represents a solid but incremental advance in the field.

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