Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.

Xing-Long Liu, Shuang Zu, Hao Yue, An-Ning Li, Ping-Ping Sun, Jian-Guo Li, Li Yan, Li-Na Ma, Shuai Zhang

College of Traditional Chinese Medicine, Jilin Agricultural Science and Technology University, Jilin 132101, China.College of Traditional Chinese Medicine, Jilin Agricultural Science and Technology University, Jilin 132101, China. · pubmed

Paper

Abstract

By establishing an

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Research summary

The paper investigates the effects of taxifolin on aging-related changes in mouse hippocampal neurons, specifically through signaling pathways associated with cellular aging. While it addresses mechanisms that could be linked to aging, the focus appears to be more on ameliorating symptoms rather than addressing the root causes of aging itself. Therefore, it contributes to the understanding of aging processes but does not present a significant breakthrough or transformative findings in the field of longevity research.

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