Advantages and disadvantages of targeting senescent endothelial cells in cardiovascular and cerebrovascular diseases based on small extracellular vesicles.
Abstract
With the growth of the aging population, age-related diseases have become a heavy global burden, particularly cardiovascular and cerebrovascular diseases (CVDs). Endothelial cell (EC) senescence constitutes an essential factor in the development of CVDs, prompting increased focus on strategies to alleviate or reverse EC senescence.
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Research summary
The paper addresses the role of endothelial cell senescence in cardiovascular and cerebrovascular diseases, which are significant age-related conditions. By focusing on targeting senescent endothelial cells, the research aims to tackle a root cause of these diseases, aligning with longevity research. However, while the findings may contribute to the understanding of senescence in the context of CVDs, the impact appears to be solid but limited, as it does not present groundbreaking insights or transformative approaches that would significantly advance the field of longevity research.
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