Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis.

Syuan-Ting Chang, Yi-Fang Chuang, Ai-Hsien Li, Yang-Teng Fan, Man-Ru Liao, I-Yu Chen, Ruo-Wei Hung, Tienyu Owen Yang, Yen-Ling Chiu

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. · pubmed

Paper

Abstract

The circulatory peripheral immune system is the most convenient approach for determining an individual's immune status. Due to various reasons, while previous studies have addressed the critical impact of age, most individual studies did not analyze immunosenescence in a systemic manner, which complicates the possibility of building a reference range for age-dependent immune profiles for effective immune monitoring. To address this gap, this study analyzed a group of healthy individuals to establish age-specific reference ranges of the healthy circulatory immune profile, and a systematic review and meta-analysis were conducted to validate the findings and create generalizable immune cell reference ranges.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the immune profile in healthy individuals across different ages, which is relevant to understanding immunosenescence—a key aspect of aging. By establishing age-specific reference ranges for immune profiles, it contributes to the broader understanding of how immune function changes with age, which is important for longevity research. However, while the findings are solid, they do not represent a major breakthrough or transformative advancement in the field, hence the moderate impact score.

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