Multi-omics evaluation of clinical-grade human umbilical cord-derived mesenchymal stem cells in synergistic improvement of aging related disorders in a senescence-accelerated mouse model.

Jiabian Lian, Lu Xia, Guohao Wang, Weijing Wu, Ping Yi, Meilin Li, Xufeng Su, Yushuo Chen, Xun Li, Fei Dou, Zhanxiang Wang

Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China. · pubmed

Paper

Abstract

The prevalence of age-related disorders, particularly in neurological and cardiovascular systems, is an increasing global health concern. Mesenchymal stem cell (MSC) therapy, particularly using human umbilical cord-derived MSCs (HUCMSCs), has shown promise in mitigating these disorders. This study investigates the effects of HUCMSCs on aging-related conditions in a senescence-accelerated mouse model (SAMP8), with a focus on DNA damage, gut microbiota alterations, and metabolic changes.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of human umbilical cord-derived mesenchymal stem cells on aging-related conditions, focusing on mechanisms such as DNA damage and metabolic changes. This aligns with longevity research as it addresses potential interventions that could mitigate the root causes of aging. However, while the study presents solid research, its impact appears limited as it primarily explores a specific therapy without significantly advancing the broader understanding of aging mechanisms or lifespan extension.

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