Trajectories and sex differences of brain structure, oxygenation and perfusion functions in normal aging.

Di Wu, Yuanhao Li, Shun Zhang, Qiuyue Chen, Jiayu Fang, Junghun Cho, Yi Wang, Su Yan, Wenzhen Zhu, Junyu Lin, Zhenxiong Wang, Yaqin Zhang

Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China. · pubmed

Paper

Abstract

Brain structure, oxygenation and perfusion are important factors in aging. Coupling between regional cerebral oxygen consumption and perfusion also reflects functions of neurovascular unit (NVU). Their trajectories and sex differences during normal aging important for clinical interpretation are still not well defined. In this study, we aim to investigate the relationship between brain structure, functions and age, and exam the sex disparities.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between brain structure, oxygenation, and perfusion in the context of normal aging, which is relevant to understanding the biological processes underlying aging. However, while it addresses important factors related to aging, it does not appear to tackle the root causes of aging or propose interventions for lifespan extension. The findings may contribute to the field but are likely to have a limited impact on advancing longevity research significantly.

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