The immunometabolic roots of aging.
Abstract
Aging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during aging and how that strongly deteriorate immune cell performance and function. Indeed, a dysfunctional immune system has been shown to have a pleiotropic impact on the organism, accelerating the overall aging process of an individual. Intrinsic and extrinsic factors are responsible for such metabolic alterations. Understanding the contribution, regulation, and connection of these different factors is fundamental to comprehend the process of aging and develop approaches to mitigate age-related immune decline. Here, we describe metabolic perturbations occurring at cellular and systemic levels. Particularly, we emphasize the interplay between metabolism and immunosenescence and describe novel interventions to protect immune function and promote health span.
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Research summary
The paper addresses the metabolic changes that contribute to immune dysfunction during aging, which is a fundamental aspect of the aging process. By exploring the interplay between metabolism and immunosenescence, it provides insights that could lead to interventions aimed at mitigating age-related decline. However, while the findings are solid and contribute to the understanding of aging, they do not present groundbreaking discoveries that would significantly advance the field, hence the moderate impact score.
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