Antiaging in a Bottle: Bioactive Competency of Plasma-Generated Nitric Oxide Water for Modulation of Aging-Related Signature in Human Dermal Cells.

Apurva Jaiswal, Neha Kaushik, Tirtha Raj Acharya, Han Sup Uhm, Eun Ha Choi, Nagendra Kumar Kaushik

Plasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Korea.Plasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Korea. · pubmed

Paper

Abstract

Nitric oxide (NO), a potential therapeutic antiaging molecule, modulates various physiological and cellular processes. However, alterations in endogenous NO levels brought on by aging impact multiple organ systems and heighten susceptibility to age-related skin diseases. This correlation underscores the importance of investigating NO-based antiaging interventions. Nonthermal plasma-generated NO is a promising avenue for cosmetic and regenerative medicine due to its capacity to stimulate cellular growth. Herein, we examine the potential of plasma-generated nitric oxide water (NOW) as a bioactive agent in human dermal fibroblasts, emphasizing gene expression patterns linked to extracellular matrix (ECM) breakdown and cellular senescence. The findings of our study indicate that administering NOW at lower dosages enhances cell migration and proliferation. Moreover, the genetic signatures associated with ECM synthesis, antioxidant defense, and antisenescence pathways have been analyzed in NOW-exposed cells. Notably, the downregulation of ECM-degrading enzyme transcripts─collagenase, elastase, and hyaluronidase─suggests NOW's potential in mitigating the intrinsic skin aging phenomena, emphasizing the promise of NO-based interventions in advancing antiaging strategies within regenerative medicine.

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Research summary

The paper investigates the potential of plasma-generated nitric oxide water as a bioactive agent in human dermal cells, focusing on gene expression related to aging and skin health. This aligns with longevity research as it explores a potential intervention that could address mechanisms of aging, particularly in skin aging. However, while the findings are interesting and contribute to the understanding of nitric oxide's role in cellular processes, the impact is limited as it primarily addresses skin aging rather than broader systemic aging mechanisms. Thus, it represents solid research but with limited implications for the wider field of longevity.

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