Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes.
Abstract
Oxidative stress generated during aging largely affects erythrocytes. Antioxidative therapies such as polyphenols and flavonoids face limitations like low bioavailability and reduced efficiency. Cerium oxide nanoparticles (CeONPs) can behave as antioxidative enzymes and thus have better efficiency. Additionally, biopolymer coatings such as polyethylene glycol and polysaccharides such as dextran enhance the biocompatibility of these NPs. Therefore, we synthesized and characterized bare, polyethylene glycol, dextran-coated CeONPs and examined their hemocompatibility and protective effect against age-induced oxidative stress in erythrocytes. Erythrocytes were obtained from 5 ml of fresh blood drawn from 52 healthy individuals aged 20-85 years with their consent. CeONPs were found to be protective against age-induced oxidative damage in erythrocytes such as reduced levels of antioxidants and increased levels of oxidative species. Pretreatment with NPs protected the morphology and membrane integrity of erythrocytes. Among the NPs investigated, dextran-coated CeONPs emerged as the most effective, providing a reassuring sign of progress in anti-aging research. Therefore, Dex-CeONPs can be used as potential antioxidant therapeutics against age-induced oxidative stress.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper investigates the protective effects of cerium oxide nanoparticles against oxidative stress in erythrocytes, which is a relevant aspect of aging research. However, while it addresses a mechanism related to oxidative damage, it does not fundamentally tackle the root causes of aging or lifespan extension. The findings may contribute to the understanding of oxidative stress in aging but represent a solid yet limited advance in the field.
Author of this paper? Send a correction.