A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation.
Abstract
The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity effect independent of its canonical mitoUPR function. Additionally, DVE-1 also influences lifespan under conditions of dietary restriction and germline loss, again distinct from its role in mitoUPR. Mechanistically, while mitochondrial stress typically prompts nuclear accumulation of DVE-1 to initiate the transcriptional mitoUPR program, these long-lived mutants reduce DVE-1 nuclear accumulation, likely by enhancing its cytosolic translocation. This observation suggests a cytosolic role for DVE-1 in lifespan extension. Overall, our study implies that, in contrast to the more narrowly defined role of the mitoUPR-related transcription factor ATFS-1, DVE-1 may possess broader functions than previously recognized in modulating longevity and defending against stress.
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Research summary
The paper investigates the role of DVE-1 in longevity regulation, specifically its functions beyond the mitochondrial unfolded protein response, which is pertinent to understanding mechanisms of lifespan extension. While the findings contribute to the field by suggesting broader roles for DVE-1, the impact appears to be solid but limited, as it builds on existing knowledge without presenting a major breakthrough or transformative insights.
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