Taxus chinensis (Pilg.) Rehder fruit attenuates aging behaviors and neuroinflammation by inhibiting microglia activation via TLR4/NF-κB/NLRP3 pathway.

Chen Meimei, Zhang Fei, Xu Wen, Lei Huangwei, Hong Zhenqiang, Yu Rongjun, Zhao Qiang, Li Qiuyang, Liu Xiaozhen, Yang Yuan, Yang Zhaoyang, Li Candong

College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China; Fujian Key Laboratory of TCM Health Status Identification, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China.College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China; Fujian Key Laboratory of TCM Health Status Identification, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China. · pubmed

Paper

Abstract

As one of the important by-products of Taxus chinensis (Pilg.) Rehder, its fruit (TCF) has a sweet taste, which is commonly used in folklore to make health care wine reputed for enhancing immune function and promoting anti-aging effects, especially popular in the longevity villages of China for a long history. Evidences had showed that Taxus chinensis fruit contained polysaccharides, flavonoids, amino acids and terpenoids, which all were free of toxic compounds, but its medicinal value has not been fully recognized. Our previous studies have found that TCF extract may reverse many biological events, including oxidative stress, inflammatory response, neuronal apoptosis, etc. by in silico methods, suggesting potential avenues for future pharmaceutical exploration in aging and age-related diseases.

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Research summary

Taxus chinensis fruit extract may attenuate aging behaviors and neuroinflammation by inhibiting microglia activation through the TLR4/NF-κB/NLRP3 pathway. The paper is relevant as it explores potential mechanisms that could address underlying biological processes associated with aging and age-related diseases, rather than merely treating symptoms.

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