Deciphering Osteosarcopenia through the hallmarks of aging.
Abstract
Osteosarcopenia is a major driver of functional loss and a risk factor for falls, fractures, disability and mortality in older adults, urgently requiring the development of effective interventions to address it. The hallmarks of aging provide a theoretical and practical framework that allows for the structured organization of current knowledge and the planning of new development lines. This article comprehensively reviews the currently available literature on the role of the hallmarks of aging in the development of osteosarcopenia, thereby offering a panoramic view of the state of the art and knowledge gaps in this field.
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Research summary
The paper addresses osteosarcopenia, which is a significant concern in the context of aging and longevity. By linking this condition to the hallmarks of aging, it attempts to explore underlying mechanisms rather than merely treating symptoms. However, while it provides a comprehensive review of existing literature and identifies knowledge gaps, it does not present novel experimental findings or interventions that would significantly advance the field, thus limiting its overall impact.
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