Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis.

Gayathiri Rajakumar, Maria Lastra Cagigas, Tian Wang, Angela Y Pan, Tiana Pelaia, Stephen J Fuller, Luigi Fontana

Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; Sydney Medical School, Nepean Clinical School, Faculty of Medicine and Health, University of Sydney, Kingswood, NSW 2747, Australia. · pubmed

Paper

Abstract

Insulin-like growth factor (IGF)-1 plays a role in aging and cancer biology, with fasting known to reduce serum IGF-1 levels in human adults. However, the impact of ad libitum ketogenic diets (KDs) on IGF-1 levels remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of ketogenic diets on IGF-1 levels, which is relevant to aging research due to IGF-1's role in aging and cancer biology. However, while the study provides a systematic review and meta-analysis, it primarily focuses on dietary impacts rather than addressing the root causes of aging or lifespan extension. Thus, it contributes solid research but has limited impact on advancing the field significantly.

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