A supramolecular fluorescence probe that simultaneously responds to viscosity and G-quadruplex for autophagy detection.

Ruiyang Bai, Dawei Yang, Ranran Sun, Xiufeng Zhang, Lei Shi, Jing Liu, Hongxia Sun, Li Yao, Yalin Tang

College of Chemistry Engineering, North China University of Science and Technology, Tangshan, 063210, PR China; Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, PR China.College of Chemistry Engineering, North China University of Science and Technology, Tangshan, 063210, PR China; Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, PR China. · pubmed

Paper

Abstract

Autophagy, as an essential physiological process in eukaryotes, has been revealed to be closely related to aging and many major diseases. Real-time in situ imaging of autophagy processes in living cells is necessary for timely detection of autophagy defects and the development of treatment methods. Currently, many studies are dedicated to the design of autophagy probes, and various types of fluorescent probes for autophagy detection have been reported. However, most of them are single fluorescence signal outputs, which may lead to non-specific signals. Nowadays a reliable and sensitive autophagy monitoring probe is still essential.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses a novel fluorescence probe for monitoring autophagy, which is indeed an essential physiological process linked to aging and age-related diseases. However, the focus is primarily on the development of a detection method rather than addressing the root causes of aging or proposing interventions that could lead to lifespan extension. The contribution is solid but does not significantly advance the field of longevity research.

Author of this paper? Send a correction.