A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study.

Joan Serrano, Saki Kondo, Grace M Link, Ian S Brown, Richard E Pratley, Kedryn K Baskin, Bret H Goodpaster, Paul M Coen, George A Kyriazis

Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA. · pubmed

Paper

Abstract

The TAS1R2 receptor, known for its role in taste perception, has also emerged as a key regulator of muscle physiology. Previous studies have shown that genetic ablation of TAS1R2 in mice enhances muscle fitness mimicking responses to endurance exercise training. However, the translational relevance of these findings to humans remains uncertain.

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Research summary

The study investigates a genetic variant associated with enhanced responses to exercise training in older adults with obesity, which could have implications for muscle physiology and fitness in the context of aging. However, while it touches on aspects of exercise and aging, it does not directly address the root causes of aging or lifespan extension. The findings may contribute to understanding how to improve health in older adults but are more incremental than groundbreaking in the broader field of longevity research.

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