Defining and characterizing neuronal senescence, 'neurescence', as G

Hannah R Hudson, Markus Riessland, Miranda E Orr

Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. · pubmed

Paper

Abstract

Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in vivo studies and human tissue indicates that postmitotic cells, including neurons, may also become senescent. The quiescent cell state of neurons and inconsistent descriptions of neuronal senescence across studies, however, have caused confusion in this burgeoning field. We summarize evidence demonstrating that exit from G

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses neuronal senescence, a phenomenon that could be linked to aging and age-related diseases. By characterizing this state in neurons, it contributes to understanding the mechanisms of cellular aging, which is relevant to longevity research. However, the impact appears to be solid but limited, as it primarily summarizes existing evidence rather than presenting groundbreaking findings or novel solutions to aging.

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