Effect of a Multifactorial Weight Loss Intervention on HDL Cholesterol Efflux Capacity and Immunosenescence: A Randomized Controlled Trial.

Laura Díez-Ricote, Esther Cuadrado-Soto, Andrés Pastor-Fernández, Gema de la Peña, Javier Martinez-Botas, Olga Castañer, M A Martínez-González, Jordi Salas-Salvado, Pablo J Fernández-Marcos, Diego Gómez-Coronado, Jose Ordovas, Lidia Daimiel

Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM+CSIC, Madrid, Spain.Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM+CSIC, Madrid, Spain. · pubmed

Paper

Abstract

Life expectancy and obesity prevalence are increasing worldwide, leading to an increase in the prevalence of cardiovascular disease. High-density lipoprotein (HDL) functionality and immunosenescence play key roles in cardiovascular disease, longevity, and quality of aging. Both molecular hallmarks of aging are impacted by obesity and metabolic syndrome and can be modulated by lifestyle. We aimed to evaluate the effect of a lifestyle intervention focused on an energy-reduced Mediterranean diet (erMedDiet), physical activity (PA), and behavioral support on HDL cholesterol efflux capacity (CEC) and immunosenescence.

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Research summary

The paper claims that a multifactorial weight loss intervention can improve HDL cholesterol efflux capacity and reduce immunosenescence. This research is relevant as it addresses lifestyle interventions that may mitigate key factors associated with aging and longevity, specifically focusing on cardiovascular health and the biological processes of aging.

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