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RESEARCH PAPER / 2024-10-08

Brown adipose tissue: a potential target for aging interventions and healthy longevity.

Hongde Li, Junli Li, Chengxiang Song, Haoran Yang, Qiang Luo, Mao Chen

Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, PR China. · pubmed

Abstract

Brown Adipose Tissue (BAT) is a type of fat tissue that can generate heat and plays an important role in regulating body temperature and energy metabolism. Enhancing BAT activity through medication, exercise and other means has become a potential effective method for treating metabolic disorders. Recently, there has been increasing evidence suggesting a link between BAT and aging. As humans age, the volume and activity of BAT decrease, which may contribute to the development of age-related diseases. Multiple organelles signaling pathways have been reported to be involved in the aging process associated with BAT. Therefore, we aimed to review the evidence related to the association between aging process and BAT decreasing, analyze the potential of BAT as a predictive marker for age-related diseases, and explore potential therapeutic strategies targeting BAT for aging interventions and healthy longevity.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the role of Brown Adipose Tissue (BAT) in the aging process and its potential as a target for interventions aimed at promoting healthy longevity. This aligns with the focus on addressing root causes of aging rather than merely treating age-related diseases. However, while the topic is significant, the paper appears to provide a review of existing evidence rather than presenting novel findings or groundbreaking research, which limits its overall impact.

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