CISD2 counteracts the inhibition of ER-mitochondrial calcium transfer by anti-apoptotic BCL-2.

Jens Loncke, Ian de Ridder, Justin Kale, Larry Wagner, Allen Kaasik, Jan B Parys, Martijn Kerkhofs, David W Andrews, David Yule, Tim Vervliet, Geert Bultynck

KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium. · pubmed

Paper

Abstract

CISD2, a 2Fe2S cluster domain-containing protein, is implicated in Wolfram syndrome type 2, longevity and cancer. CISD2 is part of a ternary complex with IP

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses CISD2's role in calcium transfer between the endoplasmic reticulum and mitochondria, which is relevant to cellular aging processes and longevity. While it touches on mechanisms that could influence aging, the findings appear to be more of a solid research contribution rather than a groundbreaking discovery. The implications for longevity are present but not sufficiently transformative to warrant a higher impact score.

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