PWWP3A deficiency accelerates testicular senescence in aged mice.

Zhen Chen, Cong Liu, Wei Qu, Yan Han, Xiaoyu Zhu, Zejia Li, Dupeng Ma, Mengya Huang, Weihao Gong, Qi Sun, Junhao Lei, Rui Guo, Mengcheng Luo

Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, China.Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, Wuhan, China. · pubmed

Paper

Abstract

The PWWP domain-containing proteins are involved in chromatin-associated biological processes, including transcriptional regulation and DNA repair, and most of them are significant for gametogenesis and early embryonic development in mammals. PWWP3A, one of the PWWP domain proteins, is a reader of H3K36me2/H3K36me3 and a response factor to DNA damage. However, the physiological role of PWWP3A in spermatogenesis and fertility remains unclear.

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Research summary

PWWP3A deficiency accelerates testicular senescence in aged mice. This study explores the role of PWWP3A in spermatogenesis and its potential implications for understanding aging processes in reproductive tissues.

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