Siwu tablet attenuates high fructose-induced glomerular podocyte senescence in rats through increasing Nup155 to promote INO80 mRNA nuclear export.

Li Chen, Tangdi Xu, Jiahao Wang, Zixuan Wang, Ying Pan, Lingdong Kong

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Chinese Medicine, Nanjing Drum Tower Hospital, School of Life Sciences, Nanjing University, Nanjing, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Siwu tablet (SWT), derived from a traditional Chinese medicinal formula named Siwu decoction, is widely used for blood deficiency syndrome. Siwu decoction and its derived formulas have been proven to improve renal anemia and prevent senescence. Whether SWT prevents glomerular podocyte senescence and the underlying molecular mechanism remains unknow.

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Research summary

Siwu tablet attenuates high fructose-induced glomerular podocyte senescence in rats through increasing Nup155 to promote INO80 mRNA nuclear export. The study addresses podocyte senescence, which is a key factor in kidney aging and dysfunction, suggesting a potential intervention for age-related renal decline.

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