Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.

Ziteng Zhang, Junxue Wang, Bowei Yu, Ying Sun, Yi Chen, Yingli Lu, Ningjian Wang, Fangzhen Xia

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

Aging plays an important role in type 2 diabetes mellitus (T2DM). But the association between accelerated biological age and T2DM, and the mechanisms underlying this association remains unclear. Thus, this study aimed to examine the associations of biological aging with T2DM, and explore the potential mediation effect of amino acids.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that accelerated biological aging is associated with an increased risk of incident type 2 diabetes, mediated by amino acids. This study is relevant as it explores the relationship between biological aging and a major age-related disease, potentially addressing underlying mechanisms rather than just symptoms.

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