Immunometabolic regulation of germinal centers and its implications for aging.

Daehong Kim, Jaemin Kim, Hyeonuk Yeo, Yeonseok Chung

Institute of Pharmaceutical Sciences, College of Pharmacy, and Seoul National University, Seoul 08826, Seoul, Republic of Korea; BK21 Plus Program, College of Pharmacy, Seoul National University, Seoul 08826, Seoul, Republic of Korea. · pubmed

Paper

Abstract

Aging, metabolism, and immunity have long been considered distinct domains. Aging is primarily associated with the gradual decline of physiological functions, metabolism regulates energy production and maintains cellular processes, and the immune system manages innate and adaptive responses against pathogens and vaccines. However, recent studies have revealed that these three systems are intricately interconnected, collectively influencing an individual's response to stress and disease. This review explores the interplay between immunometabolism, T follicular helper cells, B cells, and aging, focusing on how these interactions impact immune function in the elderly.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the interplay between immunometabolism and immune function in the context of aging, which is pertinent to understanding the biological mechanisms underlying aging and age-related decline. While it presents solid research that contributes to the field, the focus appears to be more on the interactions rather than providing groundbreaking insights or solutions to the root causes of aging. Thus, it has a limited impact overall.

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