Cellular stress and epigenetic regulation in adult stem cells.

Joey Llewellyn, Rithvik Baratam, Luka Culig, Isabel Beerman

Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. · pubmed

Paper

Abstract

Stem cells are a unique class of cells that possess the ability to differentiate and self-renew, enabling them to repair and replenish tissues. To protect and maintain the potential of stem cells, the cells and the environment surrounding these cells (stem cell niche) are highly responsive and tightly regulated. However, various stresses can affect the stem cells and their niches. These stresses are both systemic and cellular and can arise from intrinsic or extrinsic factors which would have strong implications on overall aging and certain disease states. Therefore, understanding the breadth of drivers, namely epigenetic alterations, involved in cellular stress is important for the development of interventions aimed at maintaining healthy stem cells and tissue homeostasis. In this review, we summarize published findings of epigenetic responses to replicative, oxidative, mechanical, and inflammatory stress on various types of adult stem cells.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the role of cellular stress and epigenetic regulation in adult stem cells, which is pertinent to understanding the mechanisms underlying aging and the maintenance of tissue homeostasis. While it provides a solid overview of the topic and summarizes existing findings, it does not present novel experimental data or significant new insights that would greatly advance the field. Thus, it is a solid contribution but with limited impact.

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