Plant Extracts and ω-3 Improve Short-Term Memory and Modulate the Microbiota-Gut-Brain Axis in D-galactose Model Mice.

Marie Martin, Milan Boulaire, Céline Lucas, Adrien Peltier, Line Pourtau, David Gaudout, Sophie Layé, Véronique Pallet, Corinne Joffre, Anne-Laure Dinel

Université Bordeaux, INRAE, Bordeaux INP, Nutrineuro, Bordeaux, France; Activ'Inside, 12 route de Beroy, ZA du Grand Cazeau, Beychac-et-Caillau.Université Bordeaux, INRAE, Bordeaux INP, Nutrineuro, Bordeaux, France; Activ'Inside, 12 route de Beroy, ZA du Grand Cazeau, Beychac-et-Caillau. · pubmed

Paper

Abstract

Aging, characterized by a slow and progressive alteration of cognitive functions, is associated with gut microbiota dysbiosis, low-grade chronic inflammation, as well as increased oxidative stress and neurofunctional alterations. Some nutrients, such as polyphenols, carotenoids, and omega (ω)-3 (n-3), are good candidates to prevent age-related cognitive decline, because of their immunomodulatory, antioxidant, and neuroprotective properties.

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Research summary

The paper investigates the effects of plant extracts and ω-3 fatty acids on cognitive decline in a model of aging, focusing on the microbiota-gut-brain axis. While it addresses factors associated with aging and cognitive function, it primarily explores symptomatic interventions rather than targeting the root causes of aging. The findings may contribute to understanding dietary influences on cognitive health, but the overall impact on longevity research is limited.

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