Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications.
Abstract
Diabetes induces a pro-aging state characterized by an increased abundance of senescent cells in various tissues, heightened chronic inflammation, reduced substance and energy metabolism, and a significant increase in intracellular reactive oxygen species (ROS) levels. This condition leads to mitochondrial dysfunction, including elevated oxidative stress, the accumulation of mitochondrial DNA (mtDNA) damage, mitophagy defects, dysregulation of mitochondrial dynamics, and abnormal energy metabolism. These dysfunctions result in intracellular calcium ion (Ca
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper addresses mitochondrial dysfunction and cellular senescence in the context of diabetes, which are important factors in the aging process. However, while it discusses potential therapeutic applications of hydrogen sulfide, the focus remains on treating symptoms associated with diabetes rather than addressing the root causes of aging. Thus, while it contributes to the understanding of aging-related mechanisms, its impact is limited and more incremental than groundbreaking.
Author of this paper? Send a correction.