Neurodegeneration: Effects of calorie restriction on the brain sirtuin protein levels.

Basar Atalay, Soner Dogan, Burhan Oral Gudu, Elif Yilmaz, Atakan Ayden, Umit Ozorhan, Munevver Burcu Cicekdal, Kaan Yaltirik, Isin Dogan Ekici, Bilge Guvenc Tuna

University of Yeditepe, School of Medicine, Department of Neurosurgery, Istanbul, Turkiye; University of Miami Miller School of Medicine, Department of Neurology, Neurocriticalcare, Miami, USA; Jackson Memorial Hospital, Department of Neurology, Neurocritical Care, Miami, USA. · pubmed

Paper

Abstract

Calorie restriction (CR) is suggested to activate protective mechanisms in neurodegenerative diseases (NDDs). Despite existing literature highlighting the protective role of Sirtuin (SIRT) proteins against age-related neurodegeneration (ND), no study has explored the total levels of SIRT 1, 3, and 6 proteins simultaneously in brain homogenates by ELISA following intermittent calorie restriction. Applying CR protocols in mice to induce stress, we aimed to determine whether ND would be more pronounced with ad libitum (AL) or with CR.

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Research summary

The paper investigates the effects of calorie restriction on Sirtuin protein levels in the context of neurodegeneration, which is relevant to aging and age-related diseases. However, the study appears to focus on the mechanisms of neurodegeneration rather than addressing the root causes of aging itself. The findings may contribute to understanding neurodegenerative processes but do not significantly advance the field of longevity research or lifespan extension. Thus, while it is relevant, its impact is limited.

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