Systemic comparison of molecular characteristics in different skin fibroblast senescent models.

Xiaokai Fang, Shan Zhang, Mingyang Wu, Yang Luo, Xingyu Chen, Yuan Zhou, Yu Zhang, Xiaochun Liu, Xu Yao

Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China.Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China. · pubmed

Paper

Abstract

Senescent human skin primary fibroblast (FB) models have been established for studying aging-related, proliferative, and inflammatory skin diseases. The aim of this study was to compare the transcriptome characteristics of human primary dermal FBs from children and the elderly with four senescence models.

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Research summary

The study compares the transcriptome characteristics of human primary dermal fibroblasts from children and the elderly across different senescence models. This research is relevant as it investigates the molecular characteristics of cellular senescence, which is a key factor in the aging process and age-related diseases.

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